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Peptide Hormone

Search Result - 1

HMRbase accession number	10026
Swiss-prot Accession number	P11185 (Sequence in FASTA format)
Description	Relaxin [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Balaenoptera edeni (Pigmy Bryde's whale)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea;Mysticeti; Balaenopteridae; Balaenoptera.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	54 Amino acids
Molecular weight	6071
References	1  PubMed abstract 2910872
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	RMTLSEKCCQVGCIRKDIARLC
Position of mature hormone in Pre-Hormone protein	22 Residues from position (33-54)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 2

HMRbase accession number	10293
Swiss-prot Accession number	Q9MYK8 (Sequence in FASTA format)
Description	Prorelaxin precursor (RXN) [Contains: Relaxin B chain; Relaxin Achain].
Source organism	Felis silvestris catus (Cat)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;Felinae; Felis.
Subcellular location	Secreted (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Expressed by the placenta. Exclusively detected in cells located in the lamellar placental labyrinth and absent from other placental and nonplacental uterine parts
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	180 Amino acids
Molecular weight	20360
References	1  PubMed abstract 9915995
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	SDYIRYSDRCCNVGCTRKELADLC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (157-180)
Receptor	N/A
Gene ID	493883
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 3

HMRbase accession number	10295
Swiss-prot Accession number	Q64171 (Sequence in FASTA format)
Description	Prorelaxin precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Mesocricetus auratus (Golden hamster)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Cricetidae; Cricetinae; Mesocricetus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. It bears mature young, and allows separation of the pelvic bones
Protein Length	177 Amino acids
Molecular weight	20007
References	1  PubMed abstract 7492700
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	YTSIYMSHQCCFRGCSRRSLTAAC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (154-177)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 4

HMRbase accession number	10366
Swiss-prot Accession number	Q9TRM8 (Sequence in FASTA format)
Description	Prorelaxin precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Canis familiaris (Dog)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Placenta; syncytiotrophoblast
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	177 Amino acids
Molecular weight	20563
References	1  PubMed abstract 10026098 2  PubMed abstract 1388669
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	DNYIKMSDKCCNVGCTRRELASRC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (154-177)
Receptor	Q5XM32    Detail in HMRbase
Gene ID	403742
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 5

HMRbase accession number	11209
Swiss-prot Accession number	P51454 (Sequence in FASTA format)
Description	Prorelaxin H1 precursor [Contains: Relaxin B chain; Relaxin A chain](Fragment).
Source organism	Pan troglodytes (Chimpanzee)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Pan.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Expressed in the corpus luteum of pregnancy but not in the placenta
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	166 Amino acids
Molecular weight	18731
References	1  PubMed abstract 8182365
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	QPYVALFEKCCLIGCTKRSLANYC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (143-166)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 6

HMRbase accession number	11211
Swiss-prot Accession number	P01347 (Sequence in FASTA format)
Description	Prorelaxin 1 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Rattus norvegicus (Rat)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	186 Amino acids
Molecular weight	20489
References	1  PubMed abstract 7231533 2  PubMed abstract 14659888 3  PubMed abstract 7004862
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	QSGALLSEQCCHIGCTRRSIAKLC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (163-186)
Receptor	N/A
Gene ID	25616
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 7

HMRbase accession number	11213
Swiss-prot Accession number	P51455 (Sequence in FASTA format)
Description	Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain](Fragment).
Source organism	Pan troglodytes (Chimpanzee)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Pan.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Expressed in the corpus luteum of pregnancy and in the placenta
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	166 Amino acids
Molecular weight	18761
References	1  PubMed abstract 8182365 2  PubMed abstract 8735594
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	QLYSALANKCCHVGCTKRSLARFC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (143-166)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 8

HMRbase accession number	11215
Swiss-prot Accession number	P11184 (Sequence in FASTA format)
Description	Relaxin [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Balaenoptera acutorostrata (Minke whale) (Lesser rorqual)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea;Mysticeti; Balaenopteridae; Balaenoptera.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	54 Amino acids
Molecular weight	6098
References	1  PubMed abstract 2910872
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	RMTLSEKCCQVGCIRKDIARLC
Position of mature hormone in Pre-Hormone protein	22 Residues from position (33-54)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 9

HMRbase accession number	11218
Swiss-prot Accession number	P22969 (Sequence in FASTA format)
Description	Prorelaxin precursor (RXN) [Contains: Relaxin B chain; Relaxin Achain].
Source organism	Equus caballus (Horse)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	182 Amino acids
Molecular weight	20721
References	1   Min K., Shiota K., Ogawa T.; "Molecular cloning of equine preprorelaxin cDNA."; J. Reprod. Dev. 42:171-178(1996). 2  PubMed abstract 7543295 3  PubMed abstract 2055195
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	QLSHKCCYWGCTRKELARQC
Position of mature hormone in Pre-Hormone protein	20 Residues from position (163-182)
Receptor	N/A
Gene ID	100033823
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 10

HMRbase accession number	11220
Swiss-prot Accession number	P19884 (Sequence in FASTA format)
Description	Prorelaxin precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Macaca mulatta (Rhesus macaque)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	185 Amino acids
Molecular weight	20895
References	1  PubMed abstract 2590381
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	QLYMTLSNKCCHIGCTKKSLAKFC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (162-185)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 11

HMRbase accession number	11222
Swiss-prot Accession number	P01348 (Sequence in FASTA format)
Description	Prorelaxin precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Sus scrofa (Pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	182 Amino acids
Molecular weight	20818
References	1  PubMed abstract 6897721 2  PubMed abstract 2442155 3  PubMed abstract 876374 4  PubMed abstract 851452 5  PubMed abstract 843375 6  PubMed abstract 938497 7  PubMed abstract 887933 8  PubMed abstract 622170
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	RMTLSEKCCQVGCIRKDIARLC
Position of mature hormone in Pre-Hormone protein	22 Residues from position (161-182)
Receptor	N/A
Gene ID	396891
PDB ID	1RLX   2RLX   3RLX   4RLX
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 12

HMRbase accession number	11224
Swiss-prot Accession number	P11952 (Sequence in FASTA format)
Description	Relaxin [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Raja erinacea (Little skate)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;Elasmobranchii; Squalea; Hypnosqualea; Pristiorajea; Batoidea;Rajiformes; Rajidae; Leucoraja.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	64 Amino acids
Molecular weight	7499
References	1  PubMed abstract 3827922
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	EEKMGFAKKCCAIGCSTEDFRMVC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (41-64)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 13

HMRbase accession number	11226
Swiss-prot Accession number	P11953 (Sequence in FASTA format)
Description	Relaxin [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Squalus acanthias (Spiny dogfish)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;Elasmobranchii; Squalea; Hypnosqualea; Squaliformes; Squaloidei;Squalidae; Squalus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	The function of relaxin in an oviparous species is not yet known
Protein Length	54 Amino acids
Molecular weight	5910
References	1  PubMed abstract 3780747
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	EGSPGMSSKCCTYGCTRKDISILC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (31-54)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 14

HMRbase accession number	11363
Swiss-prot Accession number	P04090 (Sequence in FASTA format)
Description	Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Isoform 1 expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 relatively abundant in placenta, much lower abundance in the prostate gland. Not detected in the ovary
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	185 Amino acids
Molecular weight	21043
References	1  PubMed abstract 6548702 2  PubMed abstract 15164053 3  PubMed abstract 15489334 4  PubMed abstract 8735594 5  PubMed abstract 10601981 6  PubMed abstract 1572287 7  PubMed abstract 2076464 8  PubMed abstract 2040595 9  PubMed abstract 1656049
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	QLYSALANKCCHVGCTKRSLARFC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (162-185)
Receptor	Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	6019
PDB ID	6RLX
Drugpedia	wiki
Comments

Search Result - 15

HMRbase accession number	11370
Swiss-prot Accession number	P04808 (Sequence in FASTA format)
Description	Prorelaxin H1 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Prostate. Not expressed in placenta, decidua or ovary
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	185 Amino acids
Molecular weight	21146
References	1  PubMed abstract 6548702 2  PubMed abstract 6298628 3  PubMed abstract 15164053 4  PubMed abstract 15489334 5  PubMed abstract 8735594 6  PubMed abstract 10601981
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	PYVALFEKCCLIGCTKRSLAKYC
Position of mature hormone in Pre-Hormone protein	23 Residues from position (163-185)
Receptor	Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	6013
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 16

HMRbase accession number	11462
Swiss-prot Accession number	P47932 (Sequence in FASTA format)
Description	Prorelaxin 1 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Mus musculus (Mouse)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	185 Amino acids
Molecular weight	20571
References	1  PubMed abstract 8452637 2  PubMed abstract 8216305
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	ESGGLMSQQCCHVGCSRRSIAKLYC
Position of mature hormone in Pre-Hormone protein	25 Residues from position (161-185)
Receptor	Q91ZZ5    Detail in HMRbase
Gene ID	19773
PDB ID	N/A
Drugpedia	wiki
Comments